来曲唑促排卵的临床观察

Clinical Observation of the Ovulation Effect of Letrozole

目的：探讨来曲唑（LE）对多囊卵巢综合症（PCOS）促排卵的临床效果。方法：选择PCOS患者100例随机分为两组，LE组55例，LE5mg／d，第5—9天口服；氯米芬（cc）组45例，CC100mg／d，第5—9天口服。分别监测HCG注射日优势卵泡数，子宫内膜厚度、形态、血清雌二醇（E2）、促黄体素（LH）水平，排卵率、妊娠率及流产率。结果：HCG注射日LE组子宫内膜较厚（P〈O．05）E2水平较低（P〈O．05），但直径≥18mm卵泡数目无明显差异（P〉0．05），临床妊娠率也无显著性差异（P〉O．05）。结论：LE有类似CC的促排卵作用及相似的妊娠率，使子宫内膜有较好的容受性，利于妊娠。

Objeetive： Discover the medical effect of Ovulation of LE on PCOS patients. Method： Select 100 PCOS patients and Divide them into 2 groups randomly. 55 patients in the LE group take 5mg/d LE orally in the 5--9 day. 45 patients in the CC group take 100mg/d CC in the 5--9 day. Detecting the num- ber of dominant follicle, endometrial thickness and form, the level of serum estradiol and luteinizing hormone on the day of HCG injection, and the ovulation rate, pregnancy rate, abortion rate. Result： On the day of HCG injection the endometrial is relatively thicker （P〈0.05） in the patients of LE group, and the level of serum estradiol is relative ly lower （P〈0.0.5）, but the number of the follicle whose diameter 18mm shows no significant differences （P〉0.05）. Also there is no significant difference in pregnancy rate （P〉0.05）. Conclusion： LE has a similar effect in ovulation and pregnancy rate like CC , provides endometrial a better receptivity and is good for pregnancy.