南通市某有机磷农药生产企业职工血清中胆碱酯酶和丙氨酸氨基转移酶活力测定结果

Study on activity of serum cholinesterase and alanine transaminase among workers in an organophosphorus pesticides factory in Nantong City

目的了解南通市2011年某有机磷农药生产企业职工血清胆碱酯酶(CHE)和丙氨酸氨基转移酶(ALT)活力测定结果,并分析相关的影响因素。方法对2011年南通市某农药厂485名职工进行职业健康检查,并分析289名有机磷作业人群(暴露组)和196名非暴露人群(对照组)的血清CHE、ALT活力检测结果。结果职业暴露组工人CHE明显低于对照组,ALT活力水平明显高于对照组。职业暴露人群不同工龄组比较:工龄≤1 a组和>10 a组CHE活力明显高于>1～10 a组,差异有统计学意义(P<0.01),≤1 a组CHE低于>10 a组(P<0.01);随着工龄的增长,ALT呈增高趋势,工龄越长,ALT水平越高,各工龄组之间差异有统计学意义(P<0.01)。女性暴露人群CHE和ALT水平均显著低于男性(P<0.01和P<0.05)。结论有机磷农药作业对职业人群的CHE、ALT影响显著,应引起足够重视,加强防护。

[ Objective]To understand the determination results of serum cholinesterase {CHE} activity and alanine transaminase （ALT） among workers in an organophosphorus pesticides factory in Nantong City during 2011, and analyze its related influencing factors. [ Methods] 485 workers in a pesticides factory in Nantong City received the occupational health examination in 2011. The determination resuhs of serum CHE and ALT activity in the exposure group 1289 workers exposed to organophosphorus pesticides ） and the control group （196 nonexposed workers} were analyzed. [ Results] The activity of serum CHE in the exposure group was significantly lower than that of the control group, and the ALT activity in the exposure group was significantly higher than that of the control group. CHE activity in working years ~〈la group and working years 〉 10a group was significantly higher than that in work- ing year 〉 1 ~ 10 a group [ P 〈 0.01 ）, and CHE activity in working years ~〈 1 a group was significantly lower than that in working years 〉 10a group （ P 〈 0.01 }. The serum ALT activity increased with the increasing working years, and there was significant difference between different working year groups { P 〈 0.01 ）. The activities of serum CHE and ALT in female workers were lower than those in male workers （P 〈 0.01 and P 〈 0.05 }. [ Conclusion] The organophosphorus pesticides exposure has a significant effect on serum CHE and ALT. It is necessary to pay attention to it and strengthen preventive measures.