尤瑞克林治疗急性脑梗死的疗效及安全性观察

The observation of the effect of urinary kallidinogenase in treatment of acute cerebral infaretion efficary and safety

目的观察尤瑞克林治疗急性脑梗死的疗效及安全性。方法 2009年1月至2011年2月我科收治的急性脑梗死患者128例,随机分为尤瑞克林治疗组(n=64)和对照组(n=64),分别观察治疗前后神经功能缺损程度(NIHSS)评分,残障评分(MRS),并随访90dMRS。结果治疗后,两组患者NIHSS和MRS评分均降低(P<0.05),尤瑞克林治疗组NIHSS,MRS及总有效率均优于对照组(P<0.05),治疗组90dMRS与治疗结束相比显著降低,与对照组90dMRS相比也显著降低(P<0.01)。结论尤瑞克林治疗急性脑梗死可显著提高患者的生活质量,改善神经功能缺损状况,降低致残率,且安全性好,值得临床推广。

Objective To obseve the effect of urinary kallidinogenase in treatment of acute cerebral infaretion efficary and safety.Methods from 2009 Janurary to 2011 February in our department in 128 patients with acute cerebral in farction were randomly divided into treatment group,Yurek Lin（n=64） and control group（n=64） were observed before and after the treatment,the degree of neural function defect score（NIHSS）,disability score（MRS）,MRS and followed up for 90 days.Results After treatment,Two groups of patients With NIHSS.and MRS were decreased（P〈0.05）,urinary kallidinogenase treatment groups NIHSS,MRS and the total effective rate were better than the control.group（P〈0.05）,treatment group90 days MRS and the end of treatment group 90 days MRS and the end of treatment significantly lower,compared with acontrol group of 90 days compared to MRS also decreased sogificantly（P〈0.01）.Conclusion Yurek Lin in treatment of acute cerebral infarction can obviously improve the quality of life of pantients,improve nellrologic deficit condition,reduce the disiablitity rate,cutting safety good,worthy of dinical applicationd.