硝呋太尔联合定君生治疗妊娠期细菌性阴道病的临床观察

Clinical surgery of nifuratel and living preparation of lactobacillus in treament for bacterial vaginosis during pregnancy

目的:评价口服硝呋太尔联合阴道置入定君生治疗妊娠期细菌性阴道病(BV)的疗效。方法:将108例妊娠期细菌性阴道病的患者随机分为两组。观察组58例,用硝呋太尔联合定君生治疗;对照组50例,单用定君生治疗,比较两组治疗结束后1周的有效率,以及治疗结束后2周、1个月及孕28～32周的复发率。结果:治疗结束后1周,观察组有效率为93.10%,对照组为88.00%,差异无统计学意义(P>0.05);复发率观察组为3.45%,对照组为24.00%,两组差异有统计学意义(P<0.01)。结论:硝呋太尔联合定君生治疗妊娠期细菌性阴道病疗效好,复发率低,安全可靠。

Objective： To discuss the curative effect of nifuratel and living preparation of lactobacillus for bacterial vaginosis dur- ing pregnancy. Methods ： 108 cases of such patients were divided into two groups . 58 patients in the study group were treated by nifuratel and living preparation of lactobacillus, another 50 patients in the control group were treated by living preparation of lacto- bacillus only. The curative effect and relapse rate were compaled after 7, 14, 30 and 28 ~ 32 gestational weeks. Results ： The ef- fective rate was 93.10% in the study roup and 88.00% in the control group after one week, but with no significant difference （P 〉 0.05）. The relapse rate was 3.45% and 24.00% in the two groups respectively with significant difference （ P 〈 0.01 ）. Conclusion：The Combination therapy is an effective and safe method with lower relapse rate.