不同分期类风湿关节炎与动脉粥样硬化的临床研究

The Clinical Research of Atherosclerosis and Different Stage in Rheumatoid Arthritis

目的利用高分辨率超声探讨类风湿关节炎X线不同分期与动脉粥样硬化形成之间的关系。方法超声检测例RA患者及例正常对照组颈动脉内一中膜厚度（IMT）判断其粥样斑块形成率，RA患者依据X线分期分为3组：A组（I期）、B组（Ⅱ期）、C组皿期和Ⅳ期），并分析之间的关系。结果RA患者动脉粥样硬化发生率明显高于对照组（P〈0.05）；但早期患者与对照组差别无统计学意义（P〈0．05），中期及晚期患者发生动脉硬化高于对照组；早期、中期、晚期终末期，动脉硬化发生率存在差别。结论RA患者更容易发生动脉硬化，随着病情进展，发生率更高。

Objective To evaluate the correlation between atheroselerosis and the X-ray stages of rheumatoid arthritis by high-resolution ultrasonography. Methods Carotid artery intima-media thickness （IMT） were studied by ultrasound in 102patients with RA and 25 normal controls. the patients were divided into three groups according X-ray stage： group A consisting of stage I , group B consisting of stage Ⅱ, group C consisting of stage mandIV. Result Compared with the subset of healthy controls, there was higher incidence of AS in RA patients, especially the group B and the group C. But the group A wasn＇t significantly higher than the subset of healthy controls. The three groups were significantly different for incidence of AS. Conclusion RA plays important role in the occurrence of AS. The incidence of AS is higher while RA is developing.