云南白药联合西咪替丁治疗新生儿消化道出血的临床疗效观察

Clinical Observation on Treatment of Neonatal Gastrointestinal Bleeding with Yunnan Baiyao Combined Cimetidine

目的:探讨云南白药联合西咪替丁治疗新生儿消化道出血的疗效。方法:奉节县人民医院住院的新生儿消化道出血患儿61例,随机分为治疗组31例和对照组30例。两组患儿均积极治疗原发疾病,同时禁食、鼻饲胃管、冰冷生理盐水洗胃,建立静脉通道补液,维生素K1止血,出血多者给予成分输血。治疗组在此基础上加用云南白药0.1 g冷盐水胃管注入胃内或者口服,每8 h 1次,西咪替丁10～15 mg/(kg.d)加入5%GS 20 mL中静脉滴注,连用3～5 d。结果:治疗组总有效率93.5%,对照组总有效率70.0%,两组比较差异有统计学意义(P<0.05)。结论:云南白药联合西咪替丁治疗新生儿消化道出血简单方便,安全有效,价格低廉,值得临床推广应用。

To investigate the efficacy of Yunnan Baiyao combined cimetidine in the treatment of neonatal gastrointestinal bleeding.Methods： Sixty-one patients of neonatal gastrointestinal bleeding were randomly divided into the treatment group（31 cases） and the control group（30 cases）.The two groups of patients received positive treatment of primary disease,at the same time given fasting,nasogastric tube,cold saline gastric lavage,intravenous access rehydration,and vitamin K1 3~10 mg infusion.On the base treatment,the treatment group received Yunnan Baiyao by stomach tube infusion or oral administration,meanwhile received cimetidine infusion 10~15 mg/（kg·d）,the treatment course was 3~5 days.Results： The total effective rate in the treatment group and control group were 93.5% and 70.0%,the difference between the two groups was statistically significant（P〈0.05）.Conclusions： It is simple,convenient,safe,effective,and inexpensive for Yunnan Baiyao combined cimetidine therapy in the treatment of neonatal gastrointestinal bleeding,so it is worthy of clinical application.