热毒宁注射液与常用输液及其他药物配伍后的变化

Compatibility and Stability of Reduning Infusion Mixtures

目的:考察热毒宁注射液与常用输液及其他药物配伍后的变化。方法:按中国药典2010版测定配伍后的pH值、不溶性微粒、光谱吸收变化。结果:热毒宁注射液用0.9%氯化钠注射液或5%葡萄糖注射液稀释后会不同程度地析出黄棕色不溶性微粒,但前者相对较少;热毒宁注射液与pH值较高的药物如含碳酸氢钠的电解质输液、阿莫西林/舒巴坦钠静脉推注液、地塞米松磷酸钠注射液等混合后颜色变黄绿色,光谱吸收曲线改变,有效成分(绿原酸)分解。结论:热毒宁注射液宜用0.9%氯化钠注射液稀释后静脉滴注,与pH值较高的药物联用时应分开注射或在不同输液间用0.9%氯化钠注射液冲管。

To study the compatibility of Reduning injection with common medicines. Methods： In accordance with the method described in China＇s pharmacopoeia 2010 edition, the pH, insoluble particle, and the changes of spectral absorption after combination were assayed. Results： Reduning injection became dark, the spectral absorption curve changed, and chlorogenic acid decomposed which was a active substance when mixed with high pH injection such as injections containing sodium bicarbonate, amoxicillim/sulbactam sodium and dexamethasone sodium phosphate. Conclusions： RedUning injection should be diluted by 0, 9% sodium chloride injection and applied intravenous infusion. Medicine combination of reduning injection and high pH medicines should be applied through separate injection or flushed perfusion tube.