家蚕先天性免疫的研究进展

Progress of Research on Bombyx Innate Immunity

蚕桑生产是我国的传统优势产业,但蚕病却给养蚕业造成很大的损失。由于产业发展的需要,家蚕的免疫防御机制是人们长期关注的热点。家蚕虽然不具有人类高度专一的获得性免疫,但具有对病原微生物感染作出快速有效应答的先天性免疫系统。家蚕受到微生物的感染后,体内会合成抗菌肽,然后抗菌肽被分泌到血淋巴中去消灭病原体。其中,模式识别受体、免疫信号传导途径以及抗菌肽在体液免疫中起着非常重要的作用。

Sericuhure production is a traditional industry in China. However,silkworm diseases have caused a great loss in economy. Due to the needs of industrial development,immune defense mechanism of the silkworm is a long-term focus of attention. Bombyx mori,although lacking an a- daptive immune system found in mammals,can resist rapidly and effectively the infection of various microorganisms through muhifaceted innate immune response. When silkworms are infected by microorganisms,the body will synthesize antimicrobial peptides which are secreted to destroy pathogens. Pattern recognition receptors,immune signaling pathways and antimicrobial peptide play a very important role in the humoral immune system.