左旋炔诺酮宫内缓释系统治疗围绝经期功血的疗效观察

Observation of therapeutic efficacy of levonorgestrel-releasing intrauterine system in the treatment of patients with perimenopausal dysfunctional uterine bleeding

目的探讨左旋炔诺酮宫内缓释系统(LNG-IUS)治疗围绝经期功能失调性子宫出血(PDUB)的疗效及不良反应。方法将双峰县妇幼保健院收治的124例PDUB患者随机分为观察组(n=62)与对照组(n=62),观察组接受LNG-IUS治疗,对照组接受小剂量米非司酮治疗。结果①治疗前,两组患者子宫内膜厚度相比差异无统计学意义(P>0.05);治疗后,观察组子宫内膜厚度显著低于对照组,两组比较差异有统计学意义(P<0.05)。②观察组治疗效果显著优于对照组,两组比较差异有统计学意义(P<0.05)。③观察组不良反应发生率低于对照组,两组比较差异有统计学意义(P<0.05)。结论 LNG-IUS治疗PDUB患者具有疗效确切、不良反应发生率低等优点,值得临床应用与推广。

Objective To explore the therapeutic efficacy and adverse reactions of patients with perimenopausal dysfunctional uterine bleeding （PDUB） treated with levonorgestrel-releasing intrauterine system（LNG-IUS ）. Methods 124 patients with PDUB who were admitted into the Maternal and Child Health Institute of Shuangfeng county were divided into observation group（n=62） and control group（n = 62）, and observation group received LNG-IUS, while control group was given low-dosage mifepristone. Results （1）Before treatment, there were no significantly differences in endometrial thickness between observation group and control group （P 〉 0.05 ）; After treatment, the endometrial thickness of observation group was significantly lower than that of control group （P 〈 0.05 ）. （2）The therapeutic efficacy of observation group was significantly better than that of control group（P 〈 0.05 ）. （3）The incidence rate of adverse reactions of observation group was significantly lower than that of control group（P 〈 0.05）. Conclusion The LNG-IUS in the treatment of patients with PDUB showes better therapeutic efficacy and lower incidence rate of adverse reactions, so this system is worthy of being applied and popularized.