摘要
目的:比较控制性超促排卵(COH)过程中血清促黄体生成素(LH)低于正常时添加基因重组LH(rLH)或人绝经期尿促性腺激素(hMG)的效果。方法:选取因输卵管因素不孕行常规IVF-ET患者85例,全部采用长方案超促排卵,均给予基因重组促卵泡激素(rFSH)进行超促排卵,超促排卵第6日时如血清LH≥1.2 mIU/ml,继续用rFSH,作为对照组(rFSH组,n=37);如血清LH<1.2 mIU/ml,则随机纳入到hMG组(rFSH+hMG,n=30)或rLH组(rFSH+rLH,n=18)。结果:3组间在促性腺激素(Gn)用量、COH天数、获卵数、双原核率、优质胚胎率、临床妊娠率方面均无统计学差异。hMG组的rFSH用量显著低于rLH组(P<0.01)。结论:在黄体期降调节长方案超促排卵第6日,如血清LH<1.2 mIU/ml时,添加hMG或rLH,可获得与对照组(rFSH组)相似的临床结果。与添加rLH组相比,添加hMG组降低了rFSH用量,减少了患者的费用。
Objective: To evaluate the effect of ovarian stimulation with rFSH+ rLH or rFSH+ LHcontaining gonadotropins(human menopausal gonadotropin,hMG) on IVF outcomes in the patients with lower than 1.2 mIU/ml serum LH.Methods: A total of 85 eligible women were enrolled in this study.As the conventional IVF treatment for tube-peritoneal factors,all patients were first undergoing luteal phase downregulation protocol,the rFSH was used for COH.Thirty-severn women with serum LH≥1.2 mIU/ml on COH day 6 were treated as the control(rFSH group),and went on using rFSH.Fourty-eight patients,with serum LH〈1.2 mIU/ml,rolled into the experimental group,they were administered rFSH with exogenous LH [18 case for rLH(rLH group) and 30 cases for hMG(hMG group)].Results: Both rLH+rFSH or hMG+rFSH combination therapy achieved similar clinical outcomes compared with to rFSH group in terms of the dose of gonadotropins,days of COH,rate of 2PN,rate of good-quality embryos and clinical pregnancy rate.However,hMG group was significantly lower than that of rLH group(P〈0.01).Conclusion: Both rLH+rFSH and hMG+rFSH administration in the patients with serum LH 〈1.2 mIU/ml on COH day 6 can achieve the same IVF clinical outcomes as rFSH group,hMG administration has advantages in reducing the doses of rFSH and therefore could reduce the costs for patients.
出处
《生殖与避孕》
CAS
CSCD
2012年第9期589-592,共4页
Reproduction and Contraception