骨髓衰竭的端粒效应
摘要
再生障碍性贫血（AA）为骨髓造血功能衰竭所致全血细胞减少的一组异质性疾病。尽管细胞免疫异常已被公认为AA发病机制中的主要环节，然仍有部分AA患者免疫抑制治疗无效。此类患者较之免疫抑制治疗有效者及同年龄正常人，其染色体端粒长度明显缩短且端粒酶活性亦存异常。笔者就AA患者端粒及其相关组成异常变化的病理生理机制进行综述。
出处
《国际输血及血液学杂志》
CAS
2012年第5期450-453,共4页
International Journal of Blood Transfusion and Hematology
参考文献24
-
1Scheinberg P, Young NS. How I treat acquired aplastic anemia. Blood, 2012,119(10) :2963-2965.
-
2Gadalla SM, Savage SA. Telomere biology in hematopoiesis and stem cell transDlantation. Blood Revo 2011,25(6):261-269.
-
3Young NS. Telomere biology and telomere diseases: implications for practice and research. Hematology Am Soc Hematol Educ Program, 2010,30-35.
-
4Aalbers AM, Kajigaya S, van den Heuvel-Eibrink MM, et al. Human telomere disease due to disruption of the CCAAT box of the TERC promoter. Blood, 2012,119(13):3060-3063.
-
5Ziegler P, Schrezenrneier H, Akkad J, et al. Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation. Ann Hematol. 2012,91(7):1115 -1120.
-
6de Lange T. How 1elomeres solve the end protection problem. Science, 2009, 326(5955);948 -952.
-
7Gadalla SM, Cawthon R, Giri N, et al. Telomere length in blood, buccal ceils, and fibroblasts from patients with inherited bone marrow failure syndromes. Aging (Albany NY), 2010, 2 (11) :867-874.
-
8Vulliamy T, Marrone A, Dokal I, et al. Association between aplastic anemia and mutations in telomerase RNA. Lancet, 2002, 359(9324) :2168-2170.
-
9Calado RT, Cooper JN, Padilla-Nash HM, et al. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. Leukemia, 2012, 26(4):700- 707.
-
10Fogarty PF,Yamaguchi H,Wiestner A, et al. Late presentation of dyskeratosis congenita as apparently acquired aplastie anemia due to mutations in telomerase RNA. Lancet, 2003, 362(9396) 1628-1630.
-
1李志春,李建忠,郭超,王郁杰,邢明礼.再生障碍性贫血-白血病综合征长期随访观察11例报告[J].中国实用内科杂志,1998,18(4):243-244.
-
2杜欣.再生障碍性贫血合并膀胱癌1例[J].临床荟萃,2012,27(22):2002-2002.
-
3李建业,崔若恒,沈尔兢.肺癌合并再生障碍性贫血3例[J].中华胸心血管外科杂志,1994,10(2):158-158. 被引量：1
-
4任梅玉,明道化.再生障碍性贫血转化为急性白血病三例[J].中华血液学杂志,1992,13(5):252-253. 被引量：1
-
5廖永葆,王勇,刘桂英,贺元元,王桂芬,刘林顺.新疆石河子地区1986～1988年白血病及再生障碍性贫血的发病情况调查[J].石河子医学院学报,1990,12(2):111-113.
-
6夏乐敏,孙思明.小牛脾提取物注射液治疗慢性再生障碍性贫血30例临床观察[J].肿瘤,2009,29(6):602-602. 被引量：1
-
7崔霞,马步成.放射性核素治疗骨转移癌[J].中日友好医院学报,2004,18(1):50-52. 被引量：2
-
8岳桂芳.太原市南郊区1986年至1988年白血病和再生障碍性贫血的流行病学调查[J].山西白血病,1993,2(3):193-194.
-
9刘竞芳,胡宗泽,张清泉.小肝癌的超声检查与临床分析(附58例分析)[J].医学影像学杂志,2001,11(2):128-129.
-
10曹萍,蒋莎义,乔晓红,谢晓恬,李福兴.骨髓衰竭小鼠动物模型的建立及碱性成纤维细胞生长因子表达[J].临床儿科杂志,2014,32(8):782-784. 被引量：1
