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基底细胞样乳腺癌中CIP2A及c-myc蛋白表达及意义 被引量：11

Expression of CIP2A and c-myc and their clinical significance in basal-like breast cancer
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摘要 目的探讨CIP2A、c-myc在基底细胞样乳腺癌(basal-like breast carcinoma,BLBC)、非基底细胞样乳腺癌(non-basal-likebreast cancer,NON-BLBC)及正常乳腺组织中的表达及其之间的相互关系。方法采用免疫组化MaxVision两步法对43例BLBC、53例NON-BLBC及20例正常乳腺组织中CIP2A、c-myc的表达进行检测。结果 CIP2A、c-myc蛋白在BLBC中的表达明显高于正常乳腺组织,且与BLBC淋巴结转移及临床分期有关,差异均有统计学意义(P<0.05)。CIP2A与c-myc蛋白的表达呈正相关(r=0.446,P<0.01)。结论 CIP2A可能与BLBC的发生、发展相关,且进一步支持CIP2A与c-myc之间的正反馈调节作用。 Purpose To detect the expression of CIP2A and c-myc in basal-like breast carcinoma （ BLBC ）, and to explore their corre- lation. Methods The expression of CIP2A and c-myc was studied in 43 cases of BLBC, 57 cases of NON-BLBC and 20 cases of nor- mal adjacent breast tissue by immunohistochemistry. Rusults The positive rate of CIP2A and c-myc protein in BLBC and NON-BLBC was much higher than that in normal breast tissue. The expression of CIP2A and c-myc was positively correlated with lymph node me- tastasis and pTNM staging of BLBC （P 〈 0.05）. Positive correlation could be found between the expression of CIP2A and that of c-myc as well （ r = 0. 446, P 〈 0. 01 ）. Conclusion CIP2A may play an important role in the carcinogenesis and development of BLBC and furthermore the study supports positive feedback regulation between the expression of CIP2A and c-myc.
作者 周炳娟 张金库 赵文明 李金梅 孙吉瑞 张丙信 乔海芝
机构地区 河北省保定市第一中心医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2012年第9期966-969,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 乳腺肿瘤 基底细胞样乳腺癌 CIP2A C-MYC breast neoplasms basal-like breast carcinoma CIP2A c-myc
分类号 R737.9 [医药卫生—肿瘤]
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参考文献17

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二级参考文献30

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共引文献28

同被引文献115

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引证文献11

二级引证文献27

临床与实验病理学杂志
2012年 第9期

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