男性2型糖尿病患者血浆致动脉粥样硬化指数相关危险因素研究

Study on the related risk factors with atherogenic index of plasma in male type 2 diabetic patients

133例男性2型糖尿病患者以血浆致动脉粥样硬化指数（AIP）0．06为切点分为非致动脉硬化表型组（N组）和致动脉硬化表型组（A组），比较2组问的临床生化指标。结果显示，A组体重指数（BMI）、腰臀比、稳态模型评估的胰岛素抵抗指数（HOMA—IR）和胰岛素分泌指数（HOMA—IS）、甘油三酯（TG）、极低密度脂蛋白胆同醇（VLDL—C）、血尿酸、尿尿酸和尿微量白蛋白（UMA）较N组明显升高（均P〈0．05），高密度脂蛋白胆固醇（HDL—C）降低（P〈0．01），冠心病发病率较高（P〈0．05）。相关分析表明，AIP与年龄、BMI、腰臀比、HOMA—IR、HOMA—IS、收缩压、舒张压、TG、总胆固醇、VLDL—C、m尿酸、尿尿酸、UMA正相关（均P〈0．05）．与HDL—C负相关（P〈0．01）。多元逐步线性回归分析表明，TG、HDL—C、VLDL—C和尿尿酸是AIP的独立影响凶素。

133 male patients with type 2 diabetes mellitus were divided into non-atherogenic phenom （ N group ） and atherogenic phenom （ A group ） according to the cutpoint of atherogenic index of plasma （AlP） at 0.06. The clinical chemistry data were compared between two groups. The results showed that body mass index （BMI） , waist-tohip ratio （WHR） , homeostasis model assessment insulin resistance index （ HOMA-IR ） and insulin secretion index （HOMA-IS）, serum triglyceride （TG）, very low density lipoprotein-cholesterol （VLDL-C）, serum uric acid （ SUA）, urine uric acid （ UUA）, and urine micro-albumin （UMA） levels in A group were higher than those in N group （ all P〈0.05） , while high density lipoprotein-cholesterol （ HDL-C ） level was lower （ P〈0.01 ）, as well as higher coronary heart disease incidence in A group as compared with N group（ P〈0.05 ）. Correlation analysis revealed that AIP was positively related with age, BMI, WHR, HOMA-IR, HOMA-IS, systolic blood pressure, diastolic blood pressure, TG, total cholesterol, VLDL-C, SUA, UUA, and UMA （ all P〈0.05 ）, and negatively related with HDL-C （P〈0.01）. Multivariant stepwise linear regression analysis revealed that TG, HDL-C, VLDL-C, and UUA were independent influential factors for AlP.