摘要
目的总结颅内软骨肉瘤的临床特点、诊疗方法和预后，为进一步改进颅内尤其是颅底软骨肉瘤的诊疗提供依据。方法对26例经病理证实的软骨肉瘤患者进行随访及回顾性分析，对其临床特点、治疗方案和预后进行分析和评价。结果26例中24例病变位于颅底，1例位于幕上，1例位于松果体区，均行手术治疗。7例全切，15例近全切，4例大部切除。12例术后行普通放疗或伽玛刀治疗，随访到22例，随访时间为6—89个月（平均41个月），4例死亡，余18例中9例脑神经功能恢复正常，5例有轻度脑神经功能不全，4例脑神经功能较术前无改善或加重。结论颅内软骨肉瘤为恶性肿瘤，大部分源于颅底，首选手术治疗，术后选择性的行普通放疗或伽玛刀治疗，预后情况与肿瘤的切除程度及病理类型密切相关，大部分患者经积极治疗有较好的预后。
Objective Through study the clinical characteristics, diagnosis, treatment and prognosis of intracranial chondrosarcoma, to improve the management of this disease. Methods The clinical data of 26 cases of intracranial chondrosarcoma confirmed by pathology from Nov. 2004 to Sep. 2011 were analyzed retrospectively, then the data of result were valued. Results 24 cases from skull base, 1 case from supratentorial and 1 case from pineal region, they were all given operated. Of 26 cases, 7 cases of totally resection, 15 cases of sub - total resection and 4 cases of gross resection. Then the 12 cases were given radiotherapy. 22 cases were followed up for 6 months to 89 months （ mean 41 months） , 4 cases died, 18 cases can recover daily life. Conclusions Intracranial chondrosarcoma are malignant tumors,and usually arise in skull base, surgery should be firstly performed, then the radiotherapy can be selected in some cases. The prognosis is related to the degree of resection and pathology. Most of cases can have a better outcome though the active therapy.
出处
《中华神经外科杂志》
CSCD
北大核心
2012年第9期923-926,共4页
Chinese Journal of Neurosurgery
基金
国家自然科学基金项目（81141028）
首都医学发展基金（2009-1040）
卫生部卫生公益性行业科研专项项目（200902004）
关键词
颅底
软骨肉瘤
显微外科手术
预后
病理
Cranial base
Chondrosarcoma
Micresurgery
Prognosis
Pathology
