加倍剂量福辛普利治疗蛋白尿的效果观察

目的研究分析使用加倍剂量福辛普利治疗肾病蛋白尿的疗效和安全性。方法将2010年1月～2011年8月收治的74例肾病蛋白尿患者随机分为两组。对照组患者每日给予10mg福辛普利治疗,试验组患者每日给予20mg福辛普利,观察对比两组患者的治疗效果和安全性。结果试验组患者治疗后尿蛋白水平低于对照组,P<0.05;两组患者不良反应比较差异无统计学意义,P>0.05。结论使用加倍剂量福辛普利治疗蛋白尿的效果较好,且具有较高的安全性,值得在临床应用。

Objective The study analyzed the efficacy and safety of doubling dose fosinopril treatment ofnephrotic proteinuria. Methods 2010 in January - August 2011 in our hospital 74 patients with nephrotic proteinuria in patients were randomLy divided into two groups. Control group were giyen daily 10mg fosinopril therapy, the experimental group were given daily 20mg Fosinopril observed compared two groups of patients the efficacy and safety. Results The experimental group after treatment, urinary protein levels lower than control group patients, P〈0.05; two groups of patients With adverse reactions was no significant difference （P〉 0.05）. Conclusion The better the effect of doubling dose fosinopril proteinuria and has a high security, worth in clinical applications.