700例女性HPV感染分型特点及相关因素分析

Characteristics of human papilloma viruses prevalence and risk profile among 700 female cases

目的探讨700例女性子宫颈感染人乳头瘤病毒(HPV)的基因分布、感染状况及其危险因素。方法对700例患者行HPV分型检测,并同时行液基细胞学检测(LCT)及填写HPV感染流行病学调查问卷。结果①HPV总感染率为12.43%,最常见的高危感染亚型为HPV39、16、58。②31～35岁、41～45岁两个年龄段感染率均高达21.5%。③HPV-H感染的影响因素多因素分析显示:宫颈细胞学分级、产次、避孕套的使用与HPV感染相关。结论 700例女性中HPV感染常见的亚型依次为HPV39、16、58型,其亚型分布在不同年龄段女性、宫颈细胞学异常患者中分布也不尽相同,产次和避孕套的使用为影响HPV感染的相关因素。

To determine the infection rate and genotypes distribution of HPV, and to analysis the highrisk of HPV infection. Methods A total of 700 patients were given an epidemical questionnaire, and exfoliated cervical cell samples were collected for both liquid-based cytology（LCT） and HPV DNA test. Results ① The overall HPV prevalence was 11.29% ,and the most common high risk types were HPV39（16. 07% ） ,16（9.20% ） and 58 （9.20%） ② HPV detection rates of 31-35 and 41-45 age groups were higher （21.5%） ,double peak was observed in the infection curve. ③ Three variables were involved in the multi-factors model：classification of cervical cytology, times of delivery, and whether using condom in sexual life. Conclusion HPV39,16,58 are the most prevalent high-risk subtypes in 700 women. HPV type distribution varies with age, and cervical dysplasia patients. The risk factors for HPV infection include times of delivery and whether using condom in sexual life.