艾廸注射液治疗老年消化道恶性肿瘤的疗效评价

Effect of AiDi injection on the old patients with gastrointestinal neoplasms

目的探讨艾廸注射液治疗老年消化道恶性肿瘤的临床疗效。方法经病理组织学或细胞学检查确诊的老年消化道恶性肿瘤患者60例,完成4～6周期化疗后,随机(用简单随机方法进行抽样)分为对照组与观察组各30例。对照组接受免疫制剂治疗,观察组接受艾廸注射液加免疫制剂治疗,其中艾廸注射液100ml,静脉滴注,1次/d,连续给药28d,每3个月1次,直到病情进展。观察2年,参照Karnofsky评分(KPS)变化评价生活质量(QOL)。结果观察组生活质量改善率明显好于对照组,P<0.05;复发和/或转移出现的时间,但两组差异无统计学意义,P>0.05;观察组无疾病进展生存时间比对照组长,P<0.05。结论艾迪注射液可以改善和稳定老年消化道恶性肿瘤患者的生活质量,患者无疾病进展生存时间延长,具有较好的临床疗效。

Objective To explore the efficacy of AiDi injection on the old patients with gastrointestinal neoplasms. Methods 60 patients were randomly divided into two groups, including control group（30 cases） and trim group（30 cases） ,AiDi in- jection combined with immunotherapy were administrated to the trial group who had finished 4 - 6 cycles chemotherapies conflnned by histopathology or cytopathology. 100ml AiDi injection, every day, 28 days every 3 months, till to progressives. Onty immunotherapy was given to the control group. The quality of life （QOL） was evaluated according to Karnofsky scores. Results The quality of life （QOL） of the trial group was more improved than that of the control（ P 〈 0.05 ）. And the times of the recurence and/or metastases of the trial group were later than that of the control（P 〉 0.05 ）. Times of PFS were prolonged in trial group（P 〈 0.05）. Conclusion The QOL and times of PFS of the old patients with gastrointestinal neoplasms may be improved and pro- longed by AiDi injection combined with immunotherapy. It is worthy of clinical generalization and further clinical investigation.