摘要
目的观察长期维持性血液透析患者(MHD)静脉补充左卡尼汀的临床疗效及不良反应。方法选择42例病情稳定1年以上的长期维持性血液透析患者,随机分为两组,治疗组于每次透析结束时静脉注射左卡尼汀1g,对照组静脉注射等量的生理盐水,共应用12周。结果静脉补充左卡尼汀组患者症状明显改善,血红蛋白、红细胞压积明显升高,血浆白蛋白及前清蛋白、转铁蛋白均有升高。药物不良反应轻微。结论左卡尼汀能有效改善维持性血液透析患者肉碱缺乏导致的临床症状。
Objective To evaluate effects and safety of L-camitine supplementation on maintenance hemodialysis patients （MHD） caused by carnitine deficiencies. Methods The experiment include forty-two MHD patients, all of them had undergone hemodialysis for at least one year before the experiment. They were randomly divided into two groups. For the therapy group, L-camitine 1 g intravenously infuse was given after every dialysissession. The observed course was 3 months. For the control group, intravenous injection normal saline was given. Results For the therapy group,improve clinical symptom significantly. Hb, Hct, serum albumin, prealbumin, transferrin were all raise. Adverse drug reactions were negligible. Conclusion L-carnitine can effectively improve clinical symptoms of maintence hemodialysis patients caused by earnitine deficiency.
出处
《四川医学》
CAS
2012年第8期1396-1398,共3页
Sichuan Medical Journal
关键词
血液透析
肉碱
左卡尼汀
hemodialysis
carnitine
L-carnitine
