性激素水平对围绝经期抑郁症的影响

Effects of sexual hormones on perimenopausal depression

目的探讨围绝经期性激素水平对抑郁症患者病情的影响。方法选取45例围绝经期抑郁症患者(A组)、50例正常围绝经期女性(B组)和50例健康生育期妇女(C组),比较三组雌二醇(E2)、促卵泡激素(FSH)、促黄体生成激素(LH)的水平差异,探讨其与抑郁程度[Hamiltom抑郁量表(HAMD)评分]的相关性。结果 A组患者的血清E2含量明显低于B、C组(P<0.05),且与HAMD评分呈负相关(r=-0.89,P<0.05)。FSH、LH在围绝经期上升,但A组与B组比较差异无统计学意义。结论围绝经期抑郁症患者E2水平下降与抑郁程度相关;检测围绝经期妇女性激素水平可早期诊断围绝经期抑郁症、评估抑郁程度。

Objective To investigate the effects of sexual hormones on perimenopausal depression.Methods Serum estradiol（E2）,follicle-stimulating hormone（FSH） and luteinizing hormone（LH） were examined in 45 patients（group A） with perimenopausal depression,50 normal perimenopausal women（group B） and 50 healthy reproductive women（group C）.The relationship between E2 and Hamiltom depression scale score（HAMD） was analyzed.Results Serum level of E2 was lower in group A than that in groups of B and C（P〈0.05）.Serum level of E2 was negatively correlated with HAMD scores in group A（r=-0.89,P〈0.05）.Serum levels of FSH and LH were elevated in groups of A and B,but which were not significantly different between groups of A and B.Conclusion Lower serum leve of E2 is closely associated with the severity of patients with perimenopausal depression.Detection of serum E2 may be useful for early diagnosis and evaluation of perimenopausal depression.