老年肺癌放疗唤起性肺炎2例并文献复习

Radiation recall pneumonitis：report of 2 cases and review of literatures

目的探讨老年人放疗唤起性肺炎的诊断和治疗。方法报告了2例老年肺癌患者放疗后应用靶向药物和抗生素治疗引起放疗唤起性肺炎的诊治过程。结果2例老年肺癌患者均接受放射治疗，在其后续治疗中发生放疗唤起性肺炎，诱导药物分别为厄洛替尼、左氧氟沙星和头孢哌酮舒巴坦。停用诱导药物和加用糖皮质激素治疗后，患者临床症状改善、肺部阴影吸收。结论放疗唤起性肺炎是一种罕见疾病，临床上容易误诊和漏诊，老年肺癌患者在接受放射治疗后的后续治疗中一定要警惕其发生。

Objective To explore the diagnosis and treatment of radiation recall pneumonitis（RRP） in elderly. Methods The diagnosis and treatment of two cases of RRP induced by targeted medicines and antibiotics after radiotherapy for lung cancer was reviewed. Results Diagnosis of RRP induced by erlotinib and levofloxacin after thoracic radiotherapy was established for the two elderly patients with lung cancer. Symptomatic and radiographic improvement was observed after withdrawal of induced drugs and application of corticosteroids. Conclusions Doctor should pay attention to RRP on the aged patients treated with antibiotics and antineoplastics after radiotherapy.