B细胞不对称分裂

Asymmetric B Cell Division

细胞的不对称分裂对于细胞多样性产生的重要性已经被大部分人所认识。B细胞的不对称分裂首先是在抗体类别转换的研究中发现的。最近，美国5科学家对B细胞在免疫发生中心中不对称分裂的原因进行了探索。结果发表在2012年1月20日出版的《Science》中。B细胞的不对称分裂参与体液免疫的抗体类别转换和抗体亲和力成熟过程。对于其机制仍不清楚，但目前研究初步提示细胞内分子的不对称分布是其发生的上游因素。并且B细胞的不对称分裂可能与不对称抗原分离可能在抗体亲和力成熟过程中具有独立协同作用。

It has been mostly accepted that asymmetric cell division is important for cell diversi- ty. Asymmetric B cell division is firstly found in the study of antibody class switch. Recently, five American scientists have addressed the asymmetric division of B cells in germinal centre. The result has been published in the journal of Science （20 January 2012）. Asymmetric B cell division is in- volved in antibody class switch and antibody affinity maturation of immunity. Although the mecha- nism of asymmetric B cell division remains unclear, the recent study implies that the molecules that display asymmetry distribution in the cell may play as upstream factors. Moreover, asymmetric B cell division and asymmetric segregation of antigen may have independent and synergistic actions in the process of antibody affinity maturation.