摘要
目的评估咪唑安定与丙泊酚在重症监护病房(ICU)机械通气患者中的镇静效果及安全性。方法将30例机械通气患者分为咪唑安定组和丙泊酚组,各15例。观察两组药物达Ramsay分级Ⅳ级所需时间、用药前及用药后1 h心率(HR)、呼吸(R)及平均动脉压(MAP)等指标。结果丙泊酚组药物起效时间、较咪唑安定组短(P<0.01)。使用前后两组HR、R及MAP等指标均无明显改变(P<0.05)。结论咪唑安定与丙泊酚在ICU中镇静治疗安全有效。
Objective To evaluate the midazolam and propofol in the intensive care unit （ICU） sedation in Mechanical Ventilation patients in efficacy and safety. Methods Thirty cases of mechanical ventilation were divided into midazolam group and propofol group, 15 cases for each group. Ramsay scores of drug were observed up to the time required for grade IV, before treatment and after lh heart rate （ HR）, respiration （R） and mean arterial pressure were measured（MAP）. Results Onset time in propofol group was shorter than that in midazolam group （ P 〈 0.01 ）. Before and after the treatment HR, R and MAP had no significant changes （ P 〈 0.05 ）. Conclusion Midazolam and propofol sedation in the ICU is a safe and effective treatment.
出处
《安徽医药》
CAS
2012年第9期1341-1342,共2页
Anhui Medical and Pharmaceutical Journal
关键词
咪唑安定
丙泊酚
机械通气
midazolam
propofol
mechanical ventilation
