血浆vaspin浓度与不稳定型心绞痛的相关性研究

Study on the Correlation Between Plasma Vaspin and Unstable Angina

【目的14g讨血浆脂肪因子vaspin浓度与不稳定型心绞痛的关系。【方法】本院收治的冠心病患者75例根据冠心病的临床类型分为不稳定型心绞痛（UAP）组：34例，稳定型心绞痛（SAP）组：41例，并选择门诊体检健康者30例作为对照组。测定各组血浆中vaspin浓度、并结合临床资料中患者血糖、血脂、高敏c反应蛋白水平进行统计分析。【结果IUAP组、SAP组血浆vaspin浓度显著低于对照组（P〈O．05）；UAP组血浆vaspin浓度显著低于SAP组（P〈O．05）；冠心病患者血浆vaspin浓度随患者血管病变支数增多而降低，Logistic回归分析显示血浆vaspin浓度与冠状动脉病变支数呈负相关（r一一0．352，P〈0．01）。【结论】血浆vaspin浓度与冠心病血管病变支数呈负相关，提示血浆vaspin对冠心痛的诊断和预测可能有重要的价值。

[Objective] To explore the correlation between plasma vaspin concentration and unstable angina. [Methods] According to clinical types of coronary heart disease, 75 patients with coronary heart disease admitted to our hospital were divided into unstable angina pectoris（UAP） group（ n = 34） and stable angina pectoris（SAp） group （ n =41）. Thirty healthy subjects in clinic service were chosen as control group. Plasma vaspin concentration of 3 groups was measured. Plasma vaspin combined with blood glucose, blood lipids and high sensitivity C reactive protein level from clinical data were statistically analyzed. [Results] Plasma vaspin in UAP group and SAP group were signif- icantly lower than that in control group（ P〈d0.05）. Plasma vaspin in UAP group was significantly lower than that in SAP group（ P〈d0.05）. Plasma vaspin in patients with coronary heart diseases decreased with the increasing of vas- cular lesion branches. Logistic regression analysis showed that plasma vaspin was negatively correlated with coronary artery lesion（r =-0. 352, P〈 0.01）. [Conclusion] Plasma vaspin has negative correlation with vascular lesion branches of coronary heart disease, which suggests that plasma vaspin may be of great value in the diagnosis and pre- diction of coronary heart disease.