摘要
【目的】探讨血清脂联素(APN)、同型半胱氨^(tHcy)、超敏C反应蛋白(hsCRP)、稳态模型评估的胰岛素抵抗指数(Homa-IR)与2型糖尿病(T2DM)大血管病变的关系。【方法】将受试者分为对照组、T2DM无血管病变组(DMl组,”=45)和大血管病变组(DM2,n一65)。测定血清APN、t-Hcy、hsCRP及相关指标,计算Homa-IR。【结果】①单因素方差分析显示,DM2组病程、腰围(wc)、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAIC)、Homa-IR、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、tHcy、hs—CRP等指标均显著高于DMl和对照组,而APN却显著低于其他两组(Pd0.05)。②多元逐步回归分析表明WC(R。一~0.37)、HOMA_IR(R。一一0.49)、hs—CRP(R。一一0.37)、tHey(R。一一0.21)是影响APN的重要因素(P〈O.05)。③Logistic回归分析显示血清APN、tHcy、hsCRP和HOMA.IR水平增高是糖尿病大血管病变的独立的危险因素。【结论】APN、tHcy、hsCRP、HOMA-IR参与了糖尿病大血管并发症的发生。APN可能通过减少炎症因子表达,减轻胰岛素抵抗,从而防治糖尿病大血管并发症的发生。
[Objective]To explore the correlation of serum adiponectin(APN), homocysteine(tHcy), high sensitive C reactive protein(hs-CRP), homeostasis model assessment of insulin resistance index(HOMA-IR) with macroangiopathy in type 2 diabetes mellitus(T2DM). [Methods] All subjects were divided into control group, T2DM without macroangiopathy group(DM1 group) and T2DM with macroangiopathy group(DM2 group). Serum APN, tHcy, hs-CRP and other factors were measured. HOMA-IR was calculated. [Results] Univariate ANOVA showed that disease course, waist circumference(WC), FPG, 2hPG, HbA1C, HOMA- IR, TG, LDL-C, Hcy and hs-CRP in DM2 group were significantly higher than those in DM1 group and con- trol group, while APN in DM2 group was significantly lower than that in other two groups( P d0.05) . Mul- tiple stepwise regression analysis showed that WC(R2 = --0.37), HOMA-IR(R2 =--0.49), hs-CRP(Rz = -- 0.37) and tHcy(R2 = --0.21) were the important factors affecting the level of APN( P d0.05). Logistic re- gression analysis showed that the increasing of serum APN, tHcy, hs-CRP and HOMA-IR were the independ- ent risk factors of macroangiopathy in T2DM. [Conclusion] APN, t-Hcy, hs-CRP and HOMA-IR participate in the pathogenesis of diabetic macrovascular complications. APN may prevent the incidence of macrovascular complications in T2DM through reducing the inflammatory factors and decreasing IR.
出处
《医学临床研究》
CAS
2012年第8期1478-1481,共4页
Journal of Clinical Research