儿童哮喘不同阶段肺炎衣原体感染情况分析

Study on the Relationship Between Chlamydia Pneumoniae Infection and Asthma in Children atDifferent Stages

【目的】探讨儿童哮喘各阶段肺炎衣原体（CP）感染状况。【方法】对儿童哮喘急性发作期（n一32）、慢性持续期（∞一35）和临床缓解期（m一29）及30例健康儿童对照纽，用ELISA方法检测肺炎衣原体血清抗体IgA、IgG、IgM。【结果】儿童哮喘急性发作期、慢性持续期和临床缓解期，健康儿童CP急性感染率分别为31．3％、25．7％、6．9％和6．6％，慢性感染率分别为18．8％、28．6％、3．5％和0％，儿童哮喘急性发作期与慢性持续期的CP感染率均显著高于临床缓解期及对照组（P〈0．05）。【结论]Ce感染是儿童哮喘急性发作期的重要诱因。

[Objective] To explore the relationship between .Chlamydia pneumoniae（CP） infection and asthma in children at different stages. [Methods]ELISA was used to detect serum CP antibodies IgA, IgG and IgM in acute attack of asthma children（n= 32）, chronic persistence of asthma children（n= 35）, clinical remis- sion of asthma children（n--29） and 30 healthy children（control group）. [Results] Acute infection rates of a- cute attack, chronic persistence and clinical remission of asthma children and healthy children were 31.3~, 25.7%, 6.9% and 6.6~, respectively, and chronic infection rates were 18.8%, 28.6~//oo, 3.5 ~ and 0 ~//0, re- spectively. Statistical analysis showed that the relationship between acute attack of asthma children and CP a- cute infection had statistical significance（ P d0.05）. The relationship between acute attack of asthma children and CP chronic infection had statistical significant （^（2 ^ 4.27, P d0.05）. The relationship between chronic persistence of asthma children and chronic CP infection had statistical significance （X2 = 8. 05, P 〈2 0. 05）. [Conclusion] CP infection is an important incentive for acute attack of asthma children.