常德地区小儿呼吸道病毒性感染病原学分析

Etiological analysis on children′s respiratory tract viral infection

目的探讨常德地区小儿呼吸道病毒性感染的病原学概况,为临床诊治工作提供参考。方法应用免疫荧光法检测患儿早期咽拭子标本中7项病毒[合胞病毒(RSV)、腺病毒(ADV)、流感病毒A(FLuA)、流感病毒B(FLuB)、副流感病毒1(PIV1)、副流感病毒2(PIV2)、副流感病毒3(PIV3)],以了解病原学分布。结果从2 778例患儿咽拭子标本中,检出相关病毒阳性1 260例,总阳性率为45.4%。含单项病毒感染占89.0%,2项混合感染占11.0%。单一病毒感染中RSV占首位(57.40%),其余依次为PIV1(11.31%)、PIV2(8.91%)、FLuB(6.33%)、ADV(5.97%)、PIV3(5.53%)、FLuA(4.55%)。结论 RSV、PIV1、PIV2为常德地区致小儿呼吸道感染的主要流行病原体。对疑似病例早期进行7项呼吸道病毒检测,尽早为临床提供病原学诊断,使患儿得到及时诊治。

Objective To investigate the etiological situation of virus infection in children＇s respiratory tract in Changde,and provide references for clinical treatment. Methods Immunofluorescenee technique was applied to detect 7 types of virus（respiratory syncytial virus（RSV）, adenovirus,influenza A, influenza 13, parainfluenza 1, parainfluenza 2 and parainfluenza 3 virus） in respiratory specimens of the children patients in their early stage. Results Among the 2 778 detected cases,] 260 cases of virus infection were detected with total positive rate of 45.4~. 89.0% of them were single virus infection and 11.0%0 were mixed viruses infection. RSV was the first causes of single infection （57.40~） ,then PIV, （11.31~//00）, PIVz （8. 91%）, FI.uB（6. 33G）, ADV（5. 97G）, PIV3 （5. 53G）, FLuA（4. 55~） were in turn. Conclusion RSV, PIV and PIVe are the primary prevalent pathogeny of children＇s respiratory tract in feetion in Changde. Detection on the 7 types of virus among the suspected cases is strongly recommended in order to provide etiological reference for clinical diagnosis.