血浆置换治疗32例肝衰竭患者的临床效果

Clinical value of liver plasma exchange on 32 patients with hepatic failure

目的探讨血浆置换治疗肝衰竭患者的临床效果。方法收集32例肝衰竭患者,在综合治疗的基础上,采用血浆置换技术对其进行治疗。分别于治疗前、后检测患者临床生化指标:天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、清蛋白(ALB)、总胆红素(TBil)、直接胆红素(DBil)、凝血酶原时间(PT)、肌酐(Cr)、国际标准化比率(INR)、总胆汁酸(TBA)。结果本组患者血浆置换治疗总有效率为78.13%。早期肝衰竭患者有效率94.73%,中期肝衰竭患者有效率70.00%,晚期肝衰竭患者全部无效死亡。生化指标AST、ALT、ALB、TBil、DBil、PT、Cr、INR、TBA治疗后较治疗前均有明显改善(P<0.05)。结论血浆置换治疗肝衰竭患者效果较好,越早治疗效果越好。

Objective To explore clinical value of liver plasma exchange on hepatic failure. Methods 32 patients with live failure were selected,they were treat by liver plasma exchange besides basic treatments. AST, ALT, ALB,TBil,DBil,PT,Cr,INR,TBA of all the patients were tested before and after treatments. Results The total effective rate was 78.13%. The effective rate of patients in early stage was 94. 73%. The effective rate of patients in middle stage was 70.00%. All the patients in advanced stage were dead. The patients had significant differences of AST,ALT,ALB,TBiI,DBil,PT,Cr,INR,TBA after treatment than before（P〈0.05）. Conclusion Liver plasma ex change has good effect on hepatic failure,it is better to treat earlier.