甲硝唑联合乳酸菌阴道胶囊治疗细菌性阴道病的临床研究

The Metronidazole combined with the Lactobacillus vaginal capsules in the treatment of bacterial vaginosis in clinical research

目的探讨甲硝唑联合乳杆菌活菌胶囊治疗细菌性阴道病的临床疗效和安全性。方法将符合诊断的60例患者采用随机数字的方法分为观察组和对照组各30例,观察患者给予乳酸菌阴道胶囊和甲硝唑阴道泡腾片,对照组仅给予甲硝唑阴道泡腾片,观察比较二者的临床疗效。结果两组患者治疗后,临床症状评分均下降(P<0.05),但是观察组患者下降幅度更大,差异存在统计学意义(P<0.05);观察组患者总有效率为96.67%,显著高于对照组的76.67%,差异存在统计学意义(P<0.05);两组患者均随访3个月,治疗后第1个月两组复发率差异无统计学意义((P>0.05),而第3个月,对照组复发率明显高于观察组(P<0.05)。结论甲硝唑联合乳酸菌阴道胶囊治疗细菌性阴道病可以有效改善患者的临床症状,临床治愈率高,远期疗效好,是治疗细菌性阴道病的有效方法之一,值得临床推广应用。

Objective To explore the combined metronidazole live Lactobacillus capsule in the treatment of bacterial vaginosis of clinical efficacy and safety. Methods With the diagnosis of 60 patients using random number method is divided into the observa- tion group and the control group with 30 cases in each group, observed in patients given Laetobacillus vaginal capsules and metronidazole vaginal effervescent tablets, the control group only received metronidazole vaginal effervescent tablets, observation of two clinical curative effect. Results The two groups of patients after treatment, the clinical symptom score were decreased （P 〈 0.05）, but in the observation group fell more sharply, differences statistically significant （P 〈 0.05）; in the observation group total effective rate was 96.67%, significantly higher than the control group in 76.67%, a statistically significant difference （P 〈 0.05）; two groups of patients were followed up for 3 months, and first months after treatment in two groups of recurrence rate have no sig- nificant difference （P 〉 0.05）, and third months, the control group significantly higher recurrence rate in the observation group P 〈 0.05）. Conclusion Metronidazole combined with Lactobacillus vaginal capsules in the treatment of bacterial vaginosis can effective- ly improve the clinical symptoms of the patients, the clinical cure rate is high, the long-term curative effect is good, is the treatment of bacterial vaginosis one effective method, it is worthy of clinical application.