基于聚甲基丙烯酸的pH敏感靶向释药性能研究

Study on the pH-sensitive target drug release property of poly(methacrylic acid)

以5-氨基水杨酸(5-ASA)为模型药物分子,pH敏感水凝胶聚甲基丙烯酸(PMAA)为载体,采用浸渍法实现了药物在载体上的负载,载药量约为23.3wt%。通过体外模拟释放实验,研究了该凝胶在不同pH值模拟胃液(pH=1.2)和模拟肠液(pH=7.5)中的释药行为。结果表明,药物在pH值较低的模拟胃液中释放的较慢,且最大累积释药率较低(～10.4%);在pH值较高的模拟肠液中释放的较快,最大累积释药率达～47.6%,并揭示了释药机理。因此,PMAA可实现药物5-ASA在模拟肠液中的靶向释放,在智能药物控释系统领域具有潜在的应用价值。

Using 5-ASA as model drug, pH--sensitive poly （methacrylic acid） as drug carriers, the drug was loaded on the carriers successfully via impregnation process. The properties of drug release under different pH values were investi- gated. In vitro test showed that the accumulated amount of drug release from PMAA was about 10. 4% in simulated gastric fluid （pH= 1.2）,while it was up to 47. 6% in simulated intestinal fluid （pH= 7. 5）. Also, the mechanism of drug release from PMAA was illustrated. There{ore, the PMAA can used as drug carriers for intestines--targeted release, and have a good potential application in intelligent controlled drug delivery system.