妊娠高血压综合征患者基质金属蛋白酶-9及血管内皮生长因子的表达及意义

Expression and in hypertensive significance of matrix metallo proteinase-9 and vascular endothelial growth factor disorders in pregnancy

目的分析妊娠高血压综合征（P1H，以下简称妊高征）患者血清基质金属蛋白酶-9（MMP-9）及血管内皮生长因子（VEGF）的表达情况，探讨二者在妊高征发病中的作用及相互关系。方法采用酶联免疫吸附（ELISA）法检测80例妊高征患者（重度25例，中度31例，轻度24例）和30例正常孕妇血清中MMP-9及VEGF的表达情况。结果妊高征患者血清中MMP-9及VEGF低于正常妊娠对照组，轻度、中度、重度妊高征组MMP-9及VEGF与正常对照组相比差异均有统计学意义（P〈0．05），中度组低于轻度组（P〈0．05），重度组低于中度组（P〈0．05）。血清MMP-9及VEGF表达呈正相关（r=0．656，P〈0．05）。结论MMP-9及VEGF参与了妊高征的病理生理改变，而且与病情严重程度有一定关系。

Objective To evaluate the role of matrix metallo proteinase-9 （MMP-9） and vascular endothelial growth factor（VEGF） in the pathogenesis of hypertensive disorders in pregnancy. Methods Serum MMP-9 and VEGF levels were determined in 80 patients with hypertensive disorders in pregnancy and 30 healthy pregnancy women by ELISA assay. Results Serum MMP-9 levels and VEGF were significantly lower in the patients with hypertensive disorders in pregnancy than those in healthy controls （ P 〈 0.05 ）. Serum MMP-9 and VEGF levels in moderate PIH were significantly lower than that in mild PIH （P 〈 0. 05 ）. Serum MMP-9 and VEGF levels in severe PIH were significantly lower than that in moderate PIH （P 〈 0. 05）. Positive correlation was found between MMP-9 and VEGF expressions. Conclusions MMP-9 and VEGF may play an important role in the change of the pathophysiology of PIH and may be used as an indicato for the severity of PIH.