摘要
目的分析妊娠高血压综合征(P1H,以下简称妊高征)患者血清基质金属蛋白酶-9(MMP-9)及血管内皮生长因子(VEGF)的表达情况,探讨二者在妊高征发病中的作用及相互关系。方法采用酶联免疫吸附(ELISA)法检测80例妊高征患者(重度25例,中度31例,轻度24例)和30例正常孕妇血清中MMP-9及VEGF的表达情况。结果妊高征患者血清中MMP-9及VEGF低于正常妊娠对照组,轻度、中度、重度妊高征组MMP-9及VEGF与正常对照组相比差异均有统计学意义(P〈0.05),中度组低于轻度组(P〈0.05),重度组低于中度组(P〈0.05)。血清MMP-9及VEGF表达呈正相关(r=0.656,P〈0.05)。结论MMP-9及VEGF参与了妊高征的病理生理改变,而且与病情严重程度有一定关系。
Objective To evaluate the role of matrix metallo proteinase-9 (MMP-9) and vascular endothelial growth factor(VEGF) in the pathogenesis of hypertensive disorders in pregnancy. Methods Serum MMP-9 and VEGF levels were determined in 80 patients with hypertensive disorders in pregnancy and 30 healthy pregnancy women by ELISA assay. Results Serum MMP-9 levels and VEGF were significantly lower in the patients with hypertensive disorders in pregnancy than those in healthy controls ( P 〈 0.05 ). Serum MMP-9 and VEGF levels in moderate PIH were significantly lower than that in mild PIH (P 〈 0. 05 ). Serum MMP-9 and VEGF levels in severe PIH were significantly lower than that in moderate PIH (P 〈 0. 05). Positive correlation was found between MMP-9 and VEGF expressions. Conclusions MMP-9 and VEGF may play an important role in the change of the pathophysiology of PIH and may be used as an indicato for the severity of PIH.
出处
《中国实用医刊》
2012年第20期34-35,共2页
Chinese Journal of Practical Medicine
关键词
妊娠高血压综合征
基质金属蛋白酶-9
血管内皮生长因子
Hypertensive disorders in pregnancy
Matrix metallo proteinase-9
Vascular endo- thelial growth factor