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细菌sRNA功能、预测及鉴定方法的研究进展 被引量：3

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摘要 生物体中除了mRNA、tRNA、rRNA三种我们熟知的RNA外，还存在大量的非编码RNA（non—coding RNA）。它们隐藏于基因组内的信息层，有学者称之为基因组内“暗物质”，不可见却执行着新层次调控基因表达的功能。
作者 赵小凯 竹俊兰 严浩 王慧利
机构地区 温州医学院生命科学学院
出处 《温州医学院学报》 CAS 2012年第5期503-507,共5页 Journal of Wenzhou Medical College
基金 国家自然科学基金资助项目(31071115 31270548) 浙江省科技厅公益项目(2011C23114)
关键词 细菌 SRNA 转录调控 生物信息学 综述文献
分类号 Q3 [生物学—遗传学]
  • 相关文献

参考文献12

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  • 2Rieder R, Reinhardt R, Sharma C, et al. Experimental tools to identify RNA-protein interactions in Helicobacter pylori [J]. RNA Biol,2012,9(4):520-531.
  • 3Ishikawa H, Otaka H, Maki K, et al. The functional Hfq- binding module of bacterial sRNAs consists of a double or single hairpin preceded by a U-rich sequence and followed by a 3' poly(U) tail[J]. Mol Microbiol,2012,18(5):1062-1074.
  • 4Papenfort K, Pfeiffer V, Mika F, et al. RNAs of Salmonella respond to membrane Etal.SigmaE dependentsmall stress by accelerating global OMP mRNA decay[J]. Mol Microbiol,2006,62:1674-1688.
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二级参考文献26

  • 1Huang HY, Chang HY, Chou CH, Tseng CP, Ho SY, Yang CD, Ju YW, Huang HD. sRNAMap: Genomic maps for small non-coding RNAs, their regulators and their targets in microbial genomes. Nucleic Acids Res, 2009, 37: D150-154.
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  • 7Babitzke P, Romeo T. CsrB sRNA family: Sequestration of RNA-binding regulatory proteins. Curr Opin Microbiol, 2007, 10(2): 156-163.
  • 8Guillier M, Gottesman S. Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs. Mol Microbiol, 2006, 59(1): 231-247.
  • 9Vecerek B, Moll I, Blasi U. Control of Fur synthesis by the non-coding RNA RyhB and iron-responsive decoding. EMBO J, 2007, 26(4): 965-975.
  • 10Masse E, Vanderpool CK, Gottesman S. Effect of RyhB small RNA on global iron use in Escherichia coli. J Bacteriol, 2005, 187(20): 6962-6971.

共引文献2

同被引文献23

  • 1Hindley J. Fractionation of 32P-labelled ribonucleic acids on polyacrylamide gels and their characterization by fingerprinting [J].J Mol Bio1,1967,30(1) :125-136.
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  • 3Kang Z, Zhang C, Zhang J, et al.Small RNA regulators in bacte- ria : powerful tools for metabolic engineering and synthetic biol- ogy[J].Appl Microhiol Biotechnol,2014,98(8);3413-3424.
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  • 5唐彬,肖斌,毛旭虎,等.细菌中非编码小RNA的筛选及鉴定[J].生命的化学,2008,28(4):477-480.
  • 6Hoe C H,Raabe C A,Rozhdestvensky T S,et al.Bacterial sR- NAs:regulation in stress[J]. Int J Med Microbio[, 2013,303 (5) :217-229.
  • 7Brantl S.Regulatory mechanisms employed by cis-encoded an- tisense RNAs[J].Curr Opin Microbiol, 2007,10 (2) : 102-109.
  • 8Dadzie I, N i B, Gong M, et al. Identification and characteriza- tion of a cis antisense RNA of the parC gene encoding DNA topoisomerase IV of Salmonella enterica serovar typhi [J]. Res Microbiol, 2014,165 (6) : 439-446.
  • 9Richards G R, Vanderpool C K. Molecular call and response: the physiology of bacterial small RNAs[J]. Biochim Biophys Acta, 2011,1809(10) : 525-531.
  • 10Caswell C C,Gaines J M, Ciborowski P, et al.Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308[J].Mol Microbiol,2012,85(2):345-360.

引证文献3

二级引证文献1

温州医学院学报
2012年 第5期

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