三阴乳腺癌的特征及治疗现状

Characters and Therapy of Triple-Negative Breast Cancer

目的探讨三阴乳腺癌的特征及治疗现状。方法以"三阴乳腺癌"、"特征"、"治疗"为关键词进行检索并筛选阅读相关文献进行综述。结果三阴乳腺癌是乳腺癌的一种特殊亚型,肿瘤细胞缺乏雌激素受体、孕激素受体及人类上皮细胞生长因子受体2,其临床特点及预后不同于其他类型的乳腺癌,发病年龄小、无病生存率及总生存率较低。目前尚缺乏针对三阴乳腺癌的治疗指南,多参照非三阴乳腺癌的治疗,主要包括外科手术治疗且保乳手术后推荐常规行放射治疗、全身化疗,靶向治疗正处于临床研究阶段。结论三阴乳腺癌是乳腺癌表现异质性特征之一,其间还存在着许多的不同点。为了改善三阴乳腺癌的预后,我们期待在将来的工作中发现更多对于三阴乳腺癌有意义的检测指标,便于制定出三阴乳腺癌个体化治疗方案。

Objective To explore the characters and therapy of the triple-negative breast cancer（TNBC）.Methods The pertinent literatures with key words＂triple-negative breast cancer＂,＂diagnosis＂,and＂therapy＂were retrieved and reviewed.Results TNBC was a subtype of breast cancer characterized by negative expressions of estrogen receptor（ER）,progesterone receptor（PR）,and human epidermal growth factor receptor-2（HER-2）.The clinicopathologic feature and prognosis of TNBC were distinct from other breast cancer.The age of onset was younger,disease free survival and total survival rate were lower in the patients with TNBC.At present,the therapy guideline was lack of TNBC,which referred to the non-TNBC,including local surgery,systemic chemotherapy,and the target therapy was at the clinical trial stage.Conclusions TNBC is one of heterogeneity characteristics for the breast cancer,which has extra much difference.For improving the TNBC prognosis,we hope that more and more significant markers to TNBC in the future are found,which are useful to make individuation treatment.