摘要
Despite great efforts in experimental and clinical research, the prognosis of pancreatic cancer (PC) has not changed significantly for decades. Detection of pre-invasive lesions or early-stage PC with small resectable cancers in asymptomatic individuals remains one of the most promising approaches to substantially improve the overall outcome of PC. Therefore, screening programs have been proposed to identify curable lesions especially in individuals with a familial or genetic predisposition for PC. In this regard, Canto et al recently contributed an important article comparing computed tomography, magnetic resonance imaging, and endoscopic ultrasound for the screening of 216 asymptomatic high-risk individuals (HRI). Pancreatic lesions were detected in 92 of 216 asymptomatic HRI (42.6%). The high diagnostic yield in this study raises several questions that need to be answered of which two will be discussed in detail in this commentary: First: which imaging test should be performed? Second and most importantly: what are we doing with incidentally detected pancreatic lesions? Which ones can be observed and which ones need to be resected?
Despite great efforts in experimental and clinical research, the prognosis of pancreatic cancer （PC） has not changed significantly for decades. Detection of pre-invasive lesions or early-stage PC with small resectable cancers in asymptomatic individuals remains one of the most promising approaches to substantially improve the overall outcome of PC. Therefore, screening programs have been proposed to identify curable lesions especially in individuals with a familial or genetic predisposition for PC. In this regard, Canto et al recently contributed an important article comparing computed tomography, magnetic resonance imaging, and endoscopic ultrasound for the screening of 216 asymptomatic high-risk individuals （HRI）. Pancreatic lesions were detected in 92 of 216 asymptomatic HRI （42.6%）. The high diagnostic yield in this study raises several questions that need to be answered of which two will be discussed in detail in this commentary： First： which imaging test should be performed？ Second and most importantly： what are we doing with incidentally detected pancreatic lesions？ Which ones can be observed and which ones need to be resected？
关键词
临床意义
胰腺癌
病变
症状
计算机断层扫描
磁共振成像
遗传倾向
HRI
Pancreatic cancer Early-stage pancreatic cancer Asymptomatic high-risk individuals Preinvasive pancreatic lesions Cystic pancreatic tumors Screening Computed tomography Magnetic resonance imaging Endoscopic ultrasound
