长沙市中老年人群代谢综合征的流行病研究

Epidemiological study on metabolic syndrome in elderly people in Changsha city

目的了解长沙市中老年人群（35～80岁）代谢综合征（metabolic syndrome，MS）的患病率及其流行病学特点，探讨其危险因素和防治对策。方法2008年10月至12月在本院行健康体检的本地中老年市民，采用整群随机抽样选取800人，进行问卷、体格、常规血生化，分析MS的分布特点及危险因素。结果长沙市中老年人群MS粗患病率为24．3％，其中男性27．9％，女性19．3％，男性显著高于女性（P〈0．01）。按2000年长沙市人口普查结果进行年龄构成比标化后，MS的患病率为24．4％，其中男性27．8％，女性21．9％（P〈0．01）；各代谢异常及MS的患病率存在性别及年龄差异；194例诊断MS的患者中，除必备组分中心性肥胖外，具有2种代谢异常的80例，占MS患者的41．2％，其中以血压升高＋糖代谢异常最多见；具有3种代谢异常的78例，占MS患者的40．2％，其中以高TG血症＋血压升高＋糖代谢异常最多见；具有4种代谢异常的36例，占MS患者的18．6％；增龄、男性、超重和（或）肥胖、高LDL—C血症、高尿酸血症、糖尿病家族史等是长沙市中老年人群MS的危险因素。结论长沙市中老年人群MS患病率及各代谢异常患病率已达较高水平。随着经济发展和人口老龄化加剧，其患病率可能进一步升高，应加强MS的早期诊断及综合防治。

Objective To assess the prevalence of metabolic syndrome （MS） and explore the asso- ciated risk factors with MS among 35 - 80 years elderly people in Changsha. Methods The survey used by cluster random sampling method （from October to December, 2008） was carried out by the Physical Exami- nation Center of the Second Xiangya Hospital, Changsha. All subjects aged from 35 to 80 years old had the questionnaires, physical examination, and biochemical measurements. MS was defined by IDF 2005. Resuits The prevalence of MS was 24. 3% among elderly people in Changsha. The prevalence of MS in male and female was 27. 9% and 19. 3%, respectively; which in male was significantly higher than in females （ P 〈0. 01 ）. According to census of 2000 in Changsha, the age-adjusted rate of MS was 24. 4% among elderly people, 27.8% in male and 21.9% in female , respectively. The metabolic abnormalities and the prevalence rate of MS were different in gender and age. Except the essential component of the central obesity in the 194 cases of MS patients, there are 80 cases include other two kinds of metabolic abnormalities , ac- counting for 41.2% , most of them with elevated blood pressure ＋ sugar metabolism disorders ; the most common three kinds of metabolic abnormalities of the 78 cases, accounting for 40. 2% of the people with MS, most of them with high TG ＋ elevated blood pressure ＋ sugar metabolism disorders; With 4 kinds of metabolic abnormalities of 36 patients, accounting for 18.6% of the MS patients. Increasing age, male, o- verweight and （or） obesity, high LDL-C hematic disease, high uric acid hematic disease, diabetes were all the risk factors of the elderly people in Changsha city. Conclusions Elderly people in Changsha have a relatively high prevalence of MS, especially for male. The prevalence of MS is considerably high in Chang- sha, which may continue to rising with the social economic development and population aging. There is an urgent need to take actions to reduce the burden of MS.