阿司匹林微丸缓释片的制备及体外释放度考察

Preparation and drug release in vitro of sustained-release pellet tablets of aspirin

目的:制备阿司匹林微丸缓释片剂。方法:采用挤出滚圆装置制备阿司匹林微丸,并在此基础上进行肠溶材料雅克宜和缓释材料SURELEASES以5∶5混合包衣。用释放度测定法考察影响药物释放的各种因素,并对阿司匹林微丸缓释片体外释药机制进行研究。结果:体外释放度试验显示,制备的阿司匹林微丸缓释片2 h内能释药30%,剩余药物在随后的10 h内缓慢释放。Weibull模型拟合方程得出药物释放符合一级速率过程,释放曲线具有明显的缓释特征。结论:成功的制备了阿司匹林微丸缓释片。

OBJECTIVE To prepare aspirin sustained-release pellet tablets.METHODS Using extrusion-spheronization equipment to prepare aspirin pellets,aspirin pellets were coated with Surelease and Acryl-EZE（5∶5） as coating material.The release mechanism of the drug from the pellet tablets was studied.RESULTS The data obtained proved that the formulation was useful for a sustained-release aspirin due to the percentage of 30% at the first two hours,and the less were released in the later 10 hours.Weibull curve fitting equations showed the pellet tablets release met level 1 rate process.CONCLUSION The method and the formulation are successful in providing slow and steady release of aspirin from sustained-release pellet tablets.