聚磷腈免疫佐剂的研究应用概况

Study and Application of Polyphosphazene Immunoadjuvant

聚磷腈免疫佐剂是一类以聚磷腈骨架为基础的新型免疫佐剂,在免疫刺激性能,药物运输性能方面具有其他佐剂无法比拟的优点。本文从聚磷腈免疫佐剂的结构特性、合成、分类、作用机理、降解性能及其微球制备等方面,阐述聚磷腈作为疫苗佐剂的优势和特点,并对聚磷腈免疫佐剂的的发展前景进行了展望。

Polyphosphazene adjuvants is an emerging type of vaccine immunoadjuvants,which is based on apolyphosphazene backbone.It has many advantages than other adjuvants especially in both immune irritancy and drug delivery performance.This paper deals with some specific aspects of Polyphosphazene adjuvants,such as structural properties,synthetic strategy,systematization,mechanism of action,degradation property of polyphosphazene as vaccine immunoadjuvants and preparation of polymer microspheres.The advantage and characteristic of polyphosphazene as vaccine immunoadjuvants have also been elaborated in this research.Ultimately,the developing prospects in this field are forecasted.