低剂量双酚A暴露与代谢综合征相关性的研究进展

Relationship of low-doses of bisphenol A exposure and metabolic syndrome: a review of recent studies

双酚A(BPA)是一种典型的环境内分泌干扰物,广泛应用于饮用水容器、食品包装材料以及多种日常生活用品的生产,对环境造成严重污染,对人类健康造成极大威胁。流行病学资料和动物实验表明,低剂量BPA暴露与代谢综合征存在一定的关联。因此确定低剂量BPA致代谢综合征的作用并明确其机制,对代谢综合征的防治具有十分重要的现实意义。该文综述了低剂量双酚A暴露与代谢综合征相关性的研究进展。

Bisphenol A （BPA）, one of the typical environmental endocrine-disrupting chemicals, is widely used in the manufacture of many daily products, such as polycarbonate plastic containers （including baby bottles and reusable water bottles）, metallic food cans, paper currencies, household electronics and so on. Human contact with BPA through various sources and there is mounting evidence suggesting that the low dose of BPA exposure plays an important role in the prevalence of metabolic syndrome. It is very important to confirm the dose-response relationship between BPA exposure and metabolic syndrome, moreover, to determine the potential mechanism through which BPA exposure acts to exert persistent effects on metabolic syndrome.