摘要
目的探讨事件相关诱发电位-听觉P300方法检测偏头痛患者认知功能改变的临床意义。方法选择发作间歇期的元先兆偏头痛患者(偏头痛组)35例和健康对照组32例进行听觉P300检测,分别比较检测结果,并对偏头痛组患者治疗后予复查。结果偏头痛组患者P300的N2波峰-基线波幅(P-B Amp)及P3的峰-峰Amp(P-PAmp)较对照组明显降低(P<0.05),潜伏期(PL)无改变(P>0.05);偏头痛组患者治疗前后P300各参数比较差异无统计学意义(P>0.05)。结论偏头痛组患者有轻度的认知功能障碍,P300检测是分析偏头痛患者认知功能较为敏感和客观的手段,而这种轻度的认知功能受损将不能随着治疗后疼痛的缓解而有所改善。
Objective To explore the signifance of cognitive impairment of migraineurs detected by event-re- lated potential（ ERP） -auditory P300. Methods Thirty-five migraineurs without aura in interval period and 32 healthy controls were examined with auditory P300. Migraineurs were examined with auditory P300 again after treatment. Re- suits The N2 peak-baseline amplitude （P-B Amp） and P3 peak-peak amplitude （P-P Amp） in migraineurs were significandy lower than those in controls. No changes of peak latency （PL） were found. There was no significant difference of all P300 parameters before and after treatment. Conclusion Migraineurs had mild cognitive impairment and P300 could be the sensitive and objective method for analyzing the cognitive function of migraineurs. The cogni- tive impairment could not be improved along with the improvement of headache.
出处
《中国临床新医学》
2012年第9期845-848,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
