摘要
轻度认知障碍(mild cognitive impairment,MCI)是介于正常老化和痴呆(AD)之间的过渡状态。目前已有较好的检测和治疗方法,能够筛查出人群中的MCI患者,通过对其进行干预,可以大大降低MCI转化为AD的概率。本文首先介绍了成本-效果分析的概念,针对MCI的特殊性对成本有进一步的思考,并采用质量调整生命年(QALY)作为评价健康生命质量的效果指标。随即对老年人中MCI人群的健康生命质量进行测度,运用Markov模型研究其用中药干预的成本-效果分析(cost-effectiveness analysis,CEA)。根据QALY及CEA的测度结果,最终得出对MCI进行早期干预的结论。
Mild cognitive impairment （MCI） is the transition state between normal aging and AD. There are better detection and treatment methods to screen a population of patients with MCI. Through intervention, the probability of MCI conversion to AD can be significantly reduced. This paper first introduces the concept of cost-effectiveness analysis, reconsiders the concept of cost for the particularity of MCI, and uses QALY to evaluate the health effects of the quality of life. Then measure the health quality of life of elderly MCI population, and use Markov model to study the cost of intervention with traditional Chinese medicine-effectiveness analysis. Finally, according to the QALY measure and CEA results, we draw the conclusion that it＇s helpful to get early intervention in MCI.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第18期2698-2701,共4页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09502-030)"中药上市后评价关键技术研究"
北京市重大课题"新医药学科群"(XK100270569)
关键词
轻度认知障碍
中药干预
成本-效果分析
质量调整生命年
MARKOV模型
mild cognitive impairment
traditional Chinese medicine intervention
cost-effectiveness analysis
quality-adjus-ted life year
Markov model
