基于HIS真实世界的参附注射液临床实效研究

Clinical outcomes research of use of Shenfu injection based on hospital information system

目的:了解参附注射液的临床应用情况,为规范参附注射液的临床应用提供参考。方法:选取全国20家大型三甲医院信息系统(hospital information system,HIS)中使用过参附注射液的患者信息,进行归纳、整理,并运用基本统计方法对适应症、用法用量、用药疗程等信息进行统计分析。结果:HIS数据库"真实世界"数据库中,使用参附注射液的患者平均年龄为62.15岁;患者主要集中在心血管内科;参附注射液在临床上主要用于治疗冠心病(中医诊断为胸痹);用药疗程多集中在3～14 d;给药剂量和疗程与药品说明书基本相符。结论:参附注射液在临床使用中多为中老年患者,其治疗疾病及使用方法基本符合药品说明书要求。

Objective： To know how Shenfu injection is used in clinical practice and to provide a reference for guiding clinical use of Shenfu injection. Method： Extract Shenfu injection＇s post-marketing re-evaluation data from the hospital information system （HIS） of 20 national grade Ⅲ-A General Hospitals, use basic statistical analysis methods to analyze Shenfu injection＇s indications, usage and dosage, treatment course etc. in clinical practice. Result： In patients using Shenfu injection, the average age was 62. 15, and patients mainly concentrated in cardiovascular medicine. In clinical practice, Shenfu injection was used mainly for treatment of coronary heart disease （diagnosed as chest obstruction in traditional Chinese medicine）. The treatment course mainly ranged from 3 to 7 days, and the dosage was within the limits prescribed by the instruction. Conclusion： Shenfu injection was mainly used for elderly patients, and has been used according to instruction in practice almostly.