含醛基及叠氮基氮杂糖中间体的合成

Syntheses of Azasugar Intermediates Containing Aldehyde Group or Azide Group

以D-甘露糖为原料,分别利用苄胺双取代和aza-Wittig反应,再经氧化和亲核取代反应,合成了带保护基的含叠氮基及醛基的五元及六元氮杂糖中间体,对相关反应条件、基团保护及反应机理等进行了探讨,并提供了一种选择性脱除三苯甲基保护基的方法.

Protected five and six membered azasugar intermediates containing aldehyde group or azide group were synthe- sized using D-mannose as starting material via benzyl amine disubstitution or aza-Wittig reaction, then the oxidation and SN2 substitution reactions, respectively. The studies on the reaction conditions, the protecting groups and the reaction mechanism were also carried out, providing a protocol to remove trityl （Tr） group selectively.