亚低温对急性呼吸窘迫综合征机械通气的影响

Effect of mild hypothermia treatment on mechanical ventilation of acute respiratory distress syndrome

目的探讨亚低温对急性呼吸窘迫综合征(ARDS)机械通气的影响及机制。方法将97例ARDS患者分为亚低温组和对照组,统计2组机械通气时间及参数变化,测定肺局部IL-6及血浆降钙素原(PCT)含量,采用呼吸末气道闭合法评估肺顺应性变化,监测机体血氧饱和度。结果与对照组相比,亚低温组机械通气时间缩短,呼吸机支持力度下降,肺局部IL-6下降,PCT下降,肺顺应性提高,动脉血氧分压提高,肺泡-动脉氧分压差下降,肺功能改善。结论亚低温对ARDS机械通气有积极影响,与改善肺功能、强化抗炎、改善氧和有关。

Objective It is to explore the effect of mild hypothermia treatment on mechanical ventilation of acute respiratory distress syndrome(ARDS) and its mechanism.Methods 97 cases of patients with ARDS were divided into mild hypothermia group and control group,the changes of mechanical ventilation times and parameters in both groups were statistied,the contents of IL-6 in local lung tissue and plasma procalcitonin(PCT) were determined,the changes of lung compliance changes were assessed by end expiratory closed respiratory airway method,the oxygen saturation was also measured.Results Compared with that in the control group,the mechanical ventilation time was shorter,ventilator support was less,the levels of IL-6 in local lung tissue and plasma PCT and alveolar-arterial oxygen were lower,the lung compliance,arterial oxygen tension and lung function were improved more in mild hypothermia group.Conclusion Mild hypothermia treatment has a good effect on mechanical ventilation,which may be related with improving lung function,strengthening anti-inflammatory effect and improving blood oxygen.