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右美托咪啶对术后阿片类需求的影响研究 被引量:5

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摘要 目的研究右美托咪啶对全麻患者术后阿片类药物需求量的影响。方法收集临床全麻患者60例,随机分为3组。Ⅰ组和Ⅱ组拔管后予右美托咪啶0.5μg/kg在15 min静脉给药。Ⅲ组不予右美托咪啶。Ⅰ组静脉自控镇痛剂量为芬太尼0.06 mg/kg、曲马多5 mg/kg加生理盐水至100 mL。Ⅱ组和Ⅲ组静脉镇痛泵量为芬太尼0.08mg/kg、曲马多6.5 mg/kg加生理盐水至100 mL。3组术后监测血压、心率、ECG ST段、中心静脉压、镇痛药需求次数、需求量及不良反应、疼痛视觉模拟评分(VAS)和镇静评分。结果Ⅰ组和Ⅱ组患者均达到满意的术后镇痛效果,镇痛指数无明显差异。Ⅰ组的心血管循环稳定,镇痛药量少,不良反应发生率低于Ⅱ组和Ⅲ组。结论全麻患者拔管后静脉镇痛前用右美托咪啶预注可减少术后阿片类药物使用量,是术后镇痛安全、有效的药物。
作者 马思杰 张清
出处 《现代中西医结合杂志》 CAS 2012年第29期3256-3258,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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  • 1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 2Kamibayashi T, Maze M. Clinical uses of alpha2 -adrenergie agonists. Anesthesiology, 2000, 93: 1345-1349.
  • 3Hall J E, Uhrich T D, Barney J A, et al. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg, 2000, 90: 699-705.
  • 4Jalowieeki P, Rudner R, Gonciarz M, et al. Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy. Anesthesiology, 2005, 103 269-273.
  • 5Lam S W, Alexander E. Dexmedetomidine use in critical care. AACN Adv Crit Care, 2008, 19: 113-120.
  • 6Ramsay M A, Luterman D L. Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology, 2004, 101: 787-790.
  • 7EbertTJ, Hall J E, Barney J A, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology, 2000, 93: 382-394.
  • 8Bhana N, Goa K L, McClellan K J. Dexmedetomidine. Drugs, 2000, 59: 263-270.
  • 9Kaygusuz K, Gokee G, Gursoy S, et al. A comparison of sedation with dexmedetomidine or propofol during shoekwave lithotripsy: a randomized controlled trial. Anesth Analg, 2008, 106: 114-119.
  • 10Tobias J D. Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology. Pediatr Crit Care Med, 2007, 8:115 131.

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  • 1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 2袁莉,王世端,阎玮,殷积慧,刘陕岭,黄辉.右美托咪啶对高血压患者麻醉诱导期间血流动力学稳定性的影响[J].中华临床医师杂志(电子版),2011,5(23):7092-7095. 被引量:34
  • 3敬勇君,曲超,姬桂荣,邹昌骝,张原,邓超,徐宝林,陈姜.不同剂量右美托咪啶复合舒芬太尼用于骨科术后镇痛的效果[J].中华临床医师杂志(电子版),2012,6(21):7001-7003. 被引量:14
  • 4叶铁虎,李大魁.麻醉药理学基础与临床[M].北京:人民卫生出版社,2011:454-456.
  • 5吴新民,许幸,王俊科,王鲲鹏,薛张纲,缪长虹,邓小明,艾登斌,于浩.静脉注射右美托咪啶辅助全身麻醉的有效性和安全性[J].中华麻醉学杂志,2007,27(9):773-776. 被引量:242
  • 6Bergese SD, Patrick Bender S, McSweeney TD, eL al. A comparative study of dexmedetomidine with midazolam and midazolam ahme hJr sedation during elective awake fibernptic intubatinn [ J ]. J Clin Aneslh,2010,22(5) :35 -40.
  • 7Tripathi DC, Shah KS, Duhey SR, ct al. Hemadynamic stress res- ponse during laparoseopic choleeysieetomy: Effect of two differenl closes of intravenous chmidine premedication [ J ]. J Anaesthesiol Clin Pharmacol,2011 ,27(4) :475 -480.
  • 8Tan JA, Ho KM. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis[J]. Intensive Care Med, 2010, 36(6): 926-939.
  • 9Wang ZY, Wang CQ, Yang JJ, et al. Which has the least immunity depression during postoperative analgesia: morphine, tramadol, or tramadol with lornoxicam?[J]. Clin Chim Acta, 2006, 369(1): 40-45.
  • 10Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care[J]. Rev Bras Anestesiol, 2012, 62(1): 118-133.

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