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GLP-1类似物和DPP-4抑制剂在1型糖尿病治疗中的应用前景 被引量：3

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摘要 1型糖尿病（T1DM）患者因自身免疫反应选择性破坏胰岛β细胞，呈现出胰岛素分泌绝对不足的临床特点，并同时伴有a细胞的胰高血糖素的不适当分泌。经典的T1DM治疗手段首选胰岛素的替代治疗。体外和体内试验均证实，
作者 涂怡婷 周智广
机构地区 中南大学湘雅二医院内分泌科、中南大学糖尿病中心、中南大学代谢内分泌研究所
出处 《广东医学》 CAS CSCD 北大核心 2012年第18期2705-2708,共4页 Guangdong Medical Journal
关键词 1型糖尿病 GLP-1类似物 替代治疗 抑制剂 胰岛素分泌 应用 自身免疫反应 胰岛Β细胞
分类号 R587.1 [医药卫生—内分泌]
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参考文献35

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同被引文献50

  • 1王燕萍,刘礼斌.GLP-1对胰岛β细胞保护作用的研究进展[J].国际内分泌代谢杂志,2007,27(2):98-100. 被引量：7
  • 2Unger RH,Oric L.Glucagon and the a cell:physiology and pathophysiology(second of two parts)[J].N Engl J Ned,1981,304(26):1575-1580.
  • 3Larsson H,Ahrén B.Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance[J].Diabetes Care,2000,23(5):650-657.
  • 4Kjems LL,Holst JJ,Volund A,et al.The influence of GLP-1 on glucose-stimulated insulin secretion:effects on beta-cell sensitivity in type 2 and nondiabetic subjects[J].Diabetes,2003,52(2):380-386.
  • 5Li Y,Hansotia T,Yusta B,et al.Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis[J].J Biol Chem,2003,278(1):471-478.
  • 6Abdul-Ghani M,De Fronzo RA.Fasting hyperglycemia impairs glucose-but not insulin-mediated suppression of glucagon secretion[J].J Clin Endocrinol Metab,2007,92(5):1778-1784.
  • 7Cryer PE.Hypoglycaemia:the limiting factor in the glycaemic management of TypeⅠand TypeⅡdiabetes[J].Diabetologia,2002,45(7):937-948.
  • 8Basu R,Chandramouli V,Dicke B,et al.Obesity and type2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis[J].Diabetes,2005,54(7):1942-1948.
  • 9Talchai C,Xuan S,Lin HV,et a1.Pancreaticβcell dedifferentiation as a mechanism of diabeticβcell failure[J].Cell,2012,150(6):1223-1234.
  • 10Collombat P,Hecksher Sorensen J,Krull J,et a1.Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression[J].J Clin Invest,2007,117(4):96l-970.

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二级引证文献11

广东医学
2012年 第18期

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