秀丽隐杆线虫脂肪沉积研究进展

Research Advance in the Regulation of Fat Deposition in Caenorhabditis elegans

脂肪的过度沉积会引发多种疾病,如心脏病、高血压、高甘油三酯血症、Ⅱ型糖尿病等。小白鼠(Mus musculus)和猪(Sus domesticus)是常用的研究脂肪沉积的模式动物,近年来随着研究的深入,发现脂肪代谢调控网络错综复杂,调控因子相互作用。秀丽隐杆线虫(Caenorhabditis elegans)具有结构简单、身体透明、便于观察、繁殖周期短、易于人工培养等特征,因此使得秀丽隐杆线虫进行脂肪调控的研究成为了可能。本文通过总结国内外线虫脂肪沉积方面的研究,综述秀丽隐杆线虫研究脂肪沉积的进展。

Excessive deposition of fat will lead to various diseases, such as heart disease, hypertension, hypertriglyceridemia, type II diabetes etc. Mice （Mus musculus） and porcine （Sus domesticus） are commonly used models for studying lipid accumulation, but more and more researches show that lipid deposition is a very complex physiological process involving in various regulation networks of fat metabolism. Many key fat regulatory genes and fat metabolism pathways found in mammals are conserved in Caenorhabditis elegans. Therefore, C. elegans is a powerful genetic model for fat biology research. This article summarizes the progress of fat deposition in C. elegans.