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大动脉炎的发病机制 被引量：4

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摘要 大动脉炎（Takayasu arteritis，TA）是我国最常见的大血管炎之一，主要累及主动脉弓及其分支，好发于青春期及24-36岁的女性，其发病有明显的种族差异，最常见于亚洲，其次是南美洲、非洲、北欧地区，西欧则罕见，其临床表现与血管病变的部位和类型，以及是否伴随血管炎症有密切关系。临床表现轻者仅为无脉搏症，重者可有神经损害、体位性头晕、癫痫发作和黑朦。常伴有发热、乏力等全身炎症反应。相比其他大血管炎，大动脉炎更易发生血栓。目前治疗主要使用糖皮质激素，当病情反复难愈或者伴有严重类固醇不良反应时则选择免疫抑制剂治疗。同时有部分患者接受外科手术和血管内重建。大动脉炎的病因尚不清楚，
作者 郭振英 孙文勇 刘震杰
机构地区 浙江省肿瘤医院病理科 浙江大学附属邵逸夫医院血管外科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2012年第10期707-710,共4页 Chinese Journal of Rheumatology
关键词 大动脉炎 发病机制 大血管炎 全身炎症反应 临床表现 糖皮质激素 免疫抑制剂 主动脉弓
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献27

  • 1Amaud L, Haroche J, Limal N,et al. Takayasu arteritis inFrance: a single-center retrospective study of 82 cases comparingwhite, north African, and black patients. Medicine (Baltimore),2010,89: 1-17.
  • 2Lee GY, Jang SY,Ko SM, et al. Cardiovascular manifestationsof Takayasu arteritis and their relationship to the disease activity:analysis of 204 Korean patients at a single center. Int J Cardiol,2011,159: 14-20.
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  • 5Amaud L,Haroche J, Toledano D, et al. Cluster analysis ofarterial involvement in Takayasu arteritis reveals symmetric ex-tension of the lesions in paired arterial beds. Arthritis Rheum,2011’ 63:1136-1140.
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同被引文献26

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引证文献4

二级引证文献8

中华风湿病学杂志
2012年 第10期

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