EGF和VEGF在创伤性骨折愈合中的变化与意义

The Significance of Changes of Serum Epidermal Growth Factor and Vascular Endothelial Growth Factor Levels Both Before and After Treatment in Patients with Fracture

目的探讨血清内皮生长因子(Epidermal Growth Factor,EGF)和血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)在创伤性骨折愈合中的变化及其意义。方法应用放射免疫分析对50例创伤性骨折患者进行了治疗前后血清EGF和VEGF检测,并与30名正常健康人作比较。结果创伤性骨折患者在治疗前后血清EGF和VEGF水平与正常对照组相比明显增高(P<0.05),手术治疗一月后两者水平与正常对照组相比差异无统计学意义(P>0.05),且治疗前后血清EGF和VEGF水平的变化呈正相关。结论血清EGF和VEGF水平与骨折愈合密切相关。

Objective To observe the clinical significance of changes of serum EGF and VEGF levels both before and after treatment in patients with facture.Methods Serum EGF and VEGF levels were determined with RIA in 50 patients with fracture and 30 normal controls.Results Before treatment,the serum EGF and VEGF levels in the patients were significantly higher than those in controls（P0.05）,and the difference were not significant（P0.05） after treatment for l month.And the serum EGF level was correlated with VEGF level.Conclusion The levels of EGF and VEGF might be correlated to the potential capability of fracture healing.