糖皮质激素对重症急性胰腺炎的疗效分析

Analysis of Glucocorticoids on Severe acute Pancreatitis

目的探讨糖皮质激素在重症急性胰腺炎治疗中的疗效。方法选取我院在2008年5至2012年6月收治急性胰腺炎患者120例作为研究对象,随机平均将其分为实验组和对照组,两组患者均给予基础综合治疗,对照组入院后即给予地塞米松20～30mg/d,静脉滴注,观察两组患者疗效。结果两组患者的腹痛腹胀消失时间、血淀粉酶恢复正常时间、平均住院时间以及平均住院费用明显优于对照组(P<0.05);应用糖皮质激素和其第一天,第三天,第七天SIRS积分明显优于对照组(P<0.05);实验组组并发症的发生率明显低于对照组(P<0.05)。结论重症急性胰腺炎患早期应用糖皮质激素可以有效的缓解临床症状,减轻其SIRS反应,提高疗效,而且并发症少,是一种安全有效的治疗方法。

Objective To investigate the efficacy of the discussion of glucocorticoids in the treatment of severe acute pancreatitis.Methods The hospital treated 120 cases of acute pancreatitis patients as research subjects,the stochastic averaging divided into experimental group and control group,patients in both groups with basic treatment control group admitted to hospital in May 2008 to June 2012 giving fluoride and dexamethasone 20-30g / d,intravenous infusion,patients were observed efficacy.Results The two groups of patients with abdominal pain,bloating disappeared,serum amylase returned to normal time,the average length of stay and average cost of hospitalization than the control group（P 0.05）;glucocorticoids and the first day of the third day,The seventh day of SIRS points higher than the control group（P 0.05）;experimental group group the incidence of complications was significantly lower than the control group（P 0.05）.Conclusion Severe acute pancreatitis with early application of glucocorticoids can effectively relieve symptoms,reduce the SIRS response,improve the efficacy and fewer complications,is a safe and effective treatment.