临床分离病原菌的分布及耐药性分析

Distribution and Drμg Resistance Analysis of Clinical Isolates of Pathogens

目的了解临床病原菌的菌种分布及耐药性。方法回顾性分析我院2010年9月至2011年8月从临床各科室送检标本中所分离病原菌的分布及耐药状况。结果共分离病原菌3262株,其中革兰阴性菌1633株,占50.1%,革兰阳性菌656株,占20.1%,真菌973株,占29.8%;分离率居前十位的细菌共1904株,占细菌总数的83.2%。除未发现耐亚胺培南和美罗培南的肠杆菌科菌株、未发现耐替考拉宁的葡萄球菌,主要病原菌均表现为相当高的多药耐药率。结论病原菌分布以革兰阴性菌为主;主要病原菌对常用抗菌药物的耐药性较为严重;加强对病原菌的耐药性监测,对有效控制感染、减少耐药菌株的产生和扩散十分必要。

Objective To investigate the distribution and drug resistance of pathogens isolated from clinical.Methods The distribution and drug resistance of pathogens isolated from clinical from December 2010 to August2011were analyzed retrospectively.Results Among 3262 strains of pathogens,including 1633 strains of gram-negative bacteria（50.1%）,656 strains of gram-positive bacteria（20.1%）and 973strainsof fungi（29.8%）.The first ten bacteria were1904strains in all,accounted for83.2%.No strain of Enterobacteriaceae resistant to imipenem and meropenem was detected.Teicoplanin-resistant Staphylococcus was not found.The Common pathogens showed relatively high multi-drug resistance.Conclusion Gram-negative bacteria were the main pathogens.The drug resistance of Common pathogens was serious.It is necessary to enhance the surveillance of drug resistance for controlling infection effectively and reducing multi-drug resistant strains.