rs501120位点基因型与糖尿病合并急性冠脉综合征病情进展的关联研究

Association between various rs501120 genotypes and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome

目的调查rs501120位点不同基因型糖尿病合并初发急性冠脉综合征患者急性冠脉综合征的再发生状况，以了解rs501120位点基因多态性与冠状动脉病变进展程度及斑块不稳定的关系。方法选取2型糖尿病合并初发急性冠脉综合征患者902例，采用TaqMan-MGB探针检测rs50112位点的单核苷酸多态性（single nucleotide polymorphism，SNP），从中选取年龄与性别相匹配的TT型、TC型与CC型病例各205例，随访观察3年，调查不同基因型人群急性冠脉综合征再发生状况。结果TT基因型人群急性冠脉综合征再发生率较CC型显著升高（TTVSCC，OR=1．7，95％CI：1．1～2．7，P=0．02），TT基因型人群心肌梗死发生率较CC型升高，差异有统计学意义（TTVSCC，OR：1．9，95％CI：1．2～3．2，P=0．007）。经Logistic回归分析去除混杂因素后，TT基因型人群对比CC基因型人群仍有显著升高的急性冠脉综合征再发风险（OR=1．6，95％CI：1．05～3．6，P=0．03）。结论rs501120位点基因多态性可能与冠状动脉病变进展程度及斑块不稳定相关。

Objective To assess the association between single nucleotide polymorphism rs501120 and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome （ACS）. Methods Nine hundred and two patients with diabetes complicated with acute coronary syndrome were enrolled. The genotype of rs501120 was determined with TaqMan-MGB probes. Two hundred and five cases of TT genotype, 205 age-and sex-frequency-matched cases of TC genotype and 205 ageand sex-frequency-matched cases of CC genotype were chosen and followed up for 3 years. Clinical data and re-occurrences of ACS were recorded. Results Patients with TT genotype had a significantly higher incidence of recurrence of ACS than those with CC genotype （TT vs. CC.. OR 1.7,95%CI 1.1-2.7,P= 0.02）. And the significance has remained even after adjusting for conventional risk factors by logistic regression （OR 1.6, 95%CI 1.05-3.6, P=0.03）. Patients with TT genotype had a significantly higher incidence of myocardial infarction than those with CC genotype（TT vs. CC： OR 1.9,95%CI 1.2-3.2,P= 0. 007）. Conclusion Our results has suggested an association between the rsS01120 polymorphism and progress of unstable coronary atherosclerotic plaque.